International Review of Ophthalmology ›› 2020, Vol. 44 ›› Issue (5): 362-365.doi: 10.3760/ cma.j.issn.1673-5803.2020.05.012

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Monokine induced by interferon-γ and thyroid associated ophthalmopathy

Tong Fei, Chen Xinxin, Mou Pei, Wei Ruili   

  1. Department of Ophthalmology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
  • Received:2020-03-11 Online:2020-10-22 Published:2020-11-01
  • Contact: Wei Ruili, Email: ruiliwei@126.com
  • Supported by:
     National Natural Science Foundation of China (81770959)

Abstract:

Monokine induced by interferon-γ（MIG）is a T-cell chemotactic factor induced by interferon-γ. In many specific autoimmune diseases, MIG is highly expressed in tissue and in serum. In patients with thyroid associated ophthalmopathy (TAO), under the combined influence of IFN-γ and TNF-α, the high level of MIG is secreted by orbital fibroblasts (OFs) and preadipocytes. The activity of TAO is related to the existence of circulating MIG, and the activity of orbital inflammation can be reflected at least in part by the increase of MIG concentration. During corticosteroid, MIG levels decreased significantly compared with baseline values in control and TAO patients. As the specific pathogenesis of TAO is not clear, it is necessary to continue to study the interaction between chemokines and cytokines in the pathogenesis of TAO.(Int Rev Ophthalmol, 2020, 44：  362-365)

Key words: monokine induced by interferon-γ, thyroid associated ophthalmopathy, autoimmune